Periplaneta americana extract
The raw material of Tianshuxin® kangfuxin Liquid (Periplaneta american), referred to as cockroach, commonly known as cockroach, belongs to the family Insecta.
Periplaneta americana is the main source of the traditional Chinese medicine "cockroach". It has been used in China for more than 2,000 years and has been recorded in medical monographs of all dynasties:
● "Shen Nong's Materia Medica" in the Han Dynasty: "It tastes salty and cold, treats blood-phlegm syndrome, cold and heat. "Compendium of Materia
Medica" of the Ming Dynasty: "can treat blood stasis, constipation, cold and heat, lower qi, and benefit blood vessels";
● "Luchuan Materia Medica" of the Qing Dynasty: "dispel wind" Relieves fever, clears blood vessels. Treats ulcers (external application)."
Source of raw materials:
Periplaneta americana is rich in amino acids, polysaccharides, cytochromes, various enzymes, as well as mineral elements, vitamins, fats and fatty acids; the medicinal active ingredients are mucoglycosine, polyols, peptides, etc. The growth environment and food composition of Periplaneta americana largely determine its component content. In order to provide Tianshuxin® Kangfuxin Liquid with high-quality raw materials with stable quality and high content of active ingredients, Kelun’s construction in Tengchong, Yunnan complies with GAP management standards At the same time, it will further carry out the selection and breeding of improved varieties, study the dynamic accumulation law of active ingredients, formulate quality control standards, and establish standardized breeding standard operating procedures (SOP) and other work.
Periplaneta americana powder is obtained by pulverizing the whole insects of Periplaneta americana after harmless killing at low temperature and drying. It contains all its active ingredients and has a wider application range than Tianshuxin® Kangfuxin Liquid, suitable for long-term use.
Modern pharmacological studies have proved that Periplaneta americana has:
1. Anti-tumor effect:
Periplaneta americana ethanol extract is effective against chronic myelogenous leukemia (K562), myeloid leukemia (HL60), mouse leukemia (P388D1) cell lines, nasopharyngeal carcinoma (CNE), lung cancer (A549), oral epithelial carcinoma (KB) in vitro ) cell lines, ovarian cancer (HO8910), cervical cancer (Hela) and prostate cancer (PC3) cell lines, esophageal cancer (Ecal09), gastric adenocarcinoma (BGC823), colon cancer (LS174T) cell lines have growth inhibitory effects; The inhibitory effect of gastric cancer BGC-823 cells was similar to that of cisplatin (DDP) in a time- and concentration-dependent manner.
Periplaneta americana extract has a certain inhibitory effect on the growth of mouse Lewis lung cancer and 3LL lung cancer tissue, and can promote tumor cell apoptosis.
2. Improve immune function:
Periplaneta americana not only has non-specific immune regulation effect on cyclophosphamide-induced immunocompromised mice, but also improves cell-specific immunity and humoral-specific immunity.
3. Hepatoprotective effect:
Periplaneta americana water extract has a certain protective effect on CCl4-induced liver injury in mice.
4. Protective effect of gastric mucosa:
Periplaneta americana ethanol extract has a significant preventive and protective effect on ethanol-induced acute gastric mucosal injury in mice; it can reduce the area of acetic acid gastric ulcer and significantly reduce the infiltration of inflammatory cells; it can inhibit gastric secretion and gastric mucosal damage. protease activity to reduce the occurrence of gastric ulcers.
5. Promote tissue repair:
Periplaneta americana can significantly promote the healing of skin burns in rats, skin scalds in rabbits and oral ulcers in guinea pigs and rabbits.
6. Anti-inflammatory and analgesic effects:
Periplaneta americana extract can inhibit xylene-induced auricle swelling in mice and egg white-induced swelling of rat feet; analgesia tests show that it is helpful to improve the threshold of skin pain receptors.
